Figure 5. Hematopoietic stem and progenitor cell (HSPC) infusion in superinfected mice promotes survival without changing pathogen clearance.

(A) Experimental design of bone marrow (BM) analysis and colony forming unit (CFU) count post HSPC infusion in superinfected mice. (B–G) BM populations of HSPCs and downstream progenitors after HSPC infusion. Bacterial load in the (H) limb and (J) spleen of infected mice. (I) Viral load of mice with or without HSPC infusion. (K) Experimental design of the survival studies on superinfected mice. (L) Survival curve after HSPC infusion. Experiments are representative of three independent experiments. (B–J) Comparison done with unpaired t-test or Welch’s t-test. (B–G) n = 5, (H–J) n = 9–11, and (L) n = 9–10 mice per group. Comparison of (L) survival was done using Log-rank (Mantel-Cox) test. ns = not significant, *p < 0.05.