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A. Assembly of the translation initiation complex eIF4F, which consists of eIF4E, eIF4G and eIF4A. eIF4E is negatively regulated by hypo-phosphorylated 4E-BP, which in turn is regulated by mTORC1. B. Structures of the small molecule inhibitors 4EGI-1 and i4EG-BiP. C. Fluorescence polarization assay for displacement of eIF4G peptide from eIF4E. Both 4EGI-1 and i4EG-BiP are capable of displacing eIF4G with similar affinities.
