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. Author manuscript; available in PMC: 2022 Jul 5.
Published in final edited form as: Eur J Med Chem. 2021 Apr 8;219:113435. doi: 10.1016/j.ejmech.2021.113435

Figure 3.

Figure 3.

A. Interaction profile of i4EG-BP. eIF4E is depicted in light blue, i4EG-BP is depicted in salmon and the side chains of eIF4E involved in the interaction are depicted in blue. B. Interaction profile of 4EGI-1. eIF4E is depicted in light blue, 4EGI-1 is depicted in salmon and the side chains of eIF4E involved in the interaction are depicted in blue. C. i4EG-BP makes hydrophobic interactions with most residues of helix α1 and α2. Hydrogen bonds are observed between the small molecule and the side chains of Gln80 and Leu85. D. 4EGI-1 makes primarily hydrophobic interactions with different residues than those interacting with i4EG-BP. A salt-bridge and hydrogen bond between the small molecule and Lys49 is also formed. E. Depiction of eIF4E residues within 4 Å of i4EG-BiP.