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A. Docking of Lenalidomide bound to Cereblon (PDB ID: 4CI2) and eIF4E bound to 4EGI-1 (PDB ID: 4TPW). Surface exposed parts of the small molecule can be arranged in proximity without steric clashes. The target degrader molecule derived from this docking pose (d4E-1) is depicted on the right. B. Synthesis of the double protected 4EGI-1 building block 7.
