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A. Structure of analyzed i4EG-BP-based PROTACs. B. Cellular Cereblon engagement assay shows intracellular activity for d4E-2 and d4E-3. C. Cell viability data for PROTACs in HeLa cells (triplicates over 24 h). D. Cellular Cereblon engagement assay used to elucidate intracellular activities of d4E-2 and d4E-3. E. Representative western blot of eIF4E degradation by d4E-4 and d4E-6 at 10 μM compound concentration.
