Table 1.

The Role of PARP1 in Skin Diseases

Target	Effects	Diseases	References
NF-κB	Proinflammatory	–	[11]
HMGB1	Proinflammatory	–	[12]
–	Anti-inflammatory	Psoriasis	[14]
–	Cell migration	Wound healing	[13]
Smad3	Fibroblast activation	Systemic sclerosis	[16]
–	Cell migration and invasion	Melanoma	[19]
CXCL1, MITF	Cell growth	Melanoma	[20,21]
Vimentin	Cell migration Metastasis	Melanoma	[22]

Abbreviations: NF-κB, nuclear factor kappa-B; HMGB1, high mobility group box-1 protein; Smad3, SMAD family member 3; CXCL1, C-X-C motif chemokine ligand 1; MITF, melanocyte inducing transcription factor.