Figure 7.

DEXs-miRNA-494-3p induces angiogenesis in MI model mice. (A) The expression levels of CD31 and VEGF in the infarcted myocardium of MI model mice induced by DEXs-miRNA-494-3p mimic were determined by immunohistochemistry. (B) Comparison of vessel counts in the infarcted area among different groups (n=6-7). ^*P<0.05 vs. DEXs blank and DEXs mimic NC. (C) The expression of CD31 and VEGF in the infarcted myocardium of MI model mice induced by DEXs-miRNA-494-3p inhibitor was determined by immunohistochemistry. (D) The mean number of CD31-positive capillaries/mm² were counted in the infarcted area in five fields per sample under an optical microscope and compared among different groups (n=6-7). ^*P<0.05 vs. DEXs blank and DEXs inhibitor NC. Magnification, x400. NS, not significant; MI, myocardial infarction; DEXs, dendritic cell-derived exosomes; VEGF, vascular endothelial growth factor; miRNA, microRNA; NC, negative control.