Table 1.
Tip60-targeted Khib sites on key residues that participate in cofactor/substrate binding, protein interactions, and cancer biomarkers.
| Gene name | Site | Function |
|---|---|---|
| PKM | 207 | ATP-binding site |
| PGK1 | 220 | ATP-binding site |
| FDPS | 123 | Isopentenyl diphosphate binding site |
| HMGCS1 | 46 | Coenzyme A binding site |
| LRPPRC | 1357 | RNA-binding site |
| PLEC | 3505 | Ovarian cancer biomarker |
| ADH5 | 107 | Breast cancer biomarker |
| PARK7 | 148 | Lung cancer biomarker |
| HSP90AB1 | 69 | Interaction with TP53, BIRC2, NR3C1 |
| LMNA | 78 | Interaction with MLIP; Spitzoid tumor gene |