Table 2.

Peak coordinates from brain regions significant in whole-brain [¹¹C]PBR28 PET voxel-wise group analyses.

Cluster size (# voxels)	Cluster p-value	Peak				Anatomical Location
		Z	x	y	z
Pandemic > Pre-Pandemic
31,504	0.0006	3.54	−20	−36	−1	L Hippocampus
		3.54	−6	2	57	L Supplementary Motor Cortex
		3.54	10	5	36	R Anterior Cingulate Cortex
		3.54	−40	–23	37	L Postcentral Gyrus
		3.54	–32	−7	46	L Precentral Gyrus
		3.54	−29	−47	43	L Superior Parietal Lobe
		3.54	−40	4	−6	L Anterior Insula
		3.54	−19	−27	54	L White Matter
		3.54	−9	11	−12	L Nucleus Accumbens
		3.54	7	23	−16	R Subcallosal Cortex
		3.54	−46	6	17	L Inferior Frontal Gyrus
		3.54	−25	3	0	L Putamen
		3.35	−20	8	48	L Superior Frontal Gyrus
		3.23	−16	6	–22	L Frontal Orbital Cortex
		3.23	−37	–22	1	L Posterior Insula
		3.23	4	−5	0	R Thalamus
		3.09	35	−1	55	L Middle Frontal Gyrus
		3.03	22	−4	−24	R Amygdala
		2.98	18	−53	25	R Precuneus Cortex
Pre-Pandemic > Pandemic
n.s.