Table 2.
Mechanical ventilation variables, laboratory variables, and treatments.
| iNO |
iEPO |
P value | |||
|---|---|---|---|---|---|
| Median | IQR | Median | IQR | ||
| Tidal volume, (ml/kg of PBW) | 7.769 | 1.360 | 7.25 | 2.6 | 0.50 |
| V̇E, (liters/min) | 12.6 | 3.1 | 15.3 | 7.8 | 0.17 |
| PEEP, (cm H2O) | 12 | 5.0 | 14 | 4.0 | 0.096 |
| Mean airway pressure, (cm H2O) | 19 | 6.0 | 21 | 7.0 | 0.036 |
| FIO2 | 100 | 30.0 | 100 | 0.0 | 0.020 |
| PAO2:FIO2, (mmHg) | 93.7 | 59.7 | 68 | 65.0 | 0.025 |
| OI | 21.9 | 12.2 | 29.4 | 29.4 | 0.012 |
| VR | 2.63 | 1.2 | 4.08 | 1.4 | 0.008 |
| pH | 7.33 | 0.13 | 7.21 | 0.17 | 0.006 |
| paCO2, (mmHg) | 49 | 14.0 | 68 | 26.0 | 0.001 |
| paO2, (mmHg) | 82 | 51.0 | 79 | 84.0 | 0.65 |
| SOFA | 8 | 4.0 | 9.5 | 4.0 | 0.035 |
| CRP, mg/L | 140 | 169.0 | 231 | 171.0 | 0.063 |
| WBC x103 /μL | 12.75 | 6.1 | 22.8 | 13.2 | 0.002 |
| Hemoglobin, g/dl | 10.9 | 3.4 | 9.15 | 3.3 | 0.24 |
| Platelets x103 /μL | 239.5 | 118.0 | 227 | 99.0 | 0.97 |
| Total bilirubin, mg/dl | 0.65 | 0.7 | 0.6 | 0.7 | 0.99 |
| Albumin, g/dl | 2.5 | 0.4 | 1.6 | 0.7 | <0.0001 |
| D-dimer, ng/ml | 2126 | 3477.0 | 2096 | 6710.0 | 0.72 |
| Creatinine, ng/dl | 1.69 | 2.2 | 2.42 | 3.5 | 0.32 |
| n (percent) | n (percent) | ||||
| Vasopressors | 48 (73%) | 13 (87%) | 0.34 | ||
| Proning | 30 (46%) | 8 (53%) | 0.58 | ||
| Therapeutic Anticoagulation | 44 (67%) | 13 (87%) | 0.13 | ||
| Neuromuscular Blockade | 36 (55%) | 13 (87%) | 0.020 | ||
| Azithromycin | 61 (88%) | 12 (80%) | 0.41 | ||
| Hydroxychloroquine | 67 (97%) | 15 (100%) | 0.67 | ||
| Nitazoxanide | 4 (6%) | 8 (53%) | <0.0001 | ||
| Remdesivir | 11 (16%) | 0 (0%) | 0.20 | ||
| Corticosteroids | 52 (75%) | 13 (87%) | 0.50 | ||
| Convalescent Plasma | 14 (20%) | 0 (0%) | 0.064 | ||
| anti-IL-6 therapy | 42 (61%) | 3 (20%) | 0.0085 | ||