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. 2022 Feb 11;15:197–207. doi: 10.2147/JAA.S337236

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© 2022 Yang et al.

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Role CASC2 in asthma ASMCs models induced by PDGF-BB. (A) Downregulation of CASC2 in ASMCs models and the cell transfection efficiency of pcDNA-CASC2 and si-CASC2. (B) Influence of CASC2 on ASMCs viability. (C) Influence of CASC2 on ASMCs migration. (D) Effect of CASC2 expression on Th1 related cytokine (IFN-γ). (E and F) Effect of CASC2 expression on Th2 related cytokines (IL-10 and IL-4). (G) Influence of CASC2 on the mRNA levels of α-SMA. ***P < 0.001 when compared with control group; ^&&P < 0.01, ^&&&P < 0.001 when compared with PDGF-BB group.

Abbreviations: CASC2, cancer susceptibility candidate-2; ASMC, airway smooth cell; PDGF-BB, platelet-derived growth factors BB; IFN-γ, interferon-γ; IL-10, interleukin-10; IL-4, interleukin-4; α-SMA, α-smooth muscle action; si-NC, negative control of the interfering RNA against CASC2; mRNA, message RNA.