FIGURE 3.

The mechanism of crosstalk between Nrf2 and NF-κB pathways. (A) Nrf2 and NF-κB compete for CBP binding in the nucleus; binding of either transcription factor to CBP is dependent on the relative amount of translocated Nrf2 and NF-κB. (B) NF-κB-recruited HDAC3 deacetylates Nrf2 inhibiting ARE-dependent gene expression. (C) Nrf2 is indirectly activated by anti-inflammatory compounds that suppress NF-κB activity; likewise, NF-κB is indirectly activated by Nrf2 inhibitors. (D) HO-1, a downstream gene of Nrf2, can inhibit NF-κB transcription. Abbreviations: CBP, CREB-binding proteins; HDACs, histone deacetylases; Ac, deacetylation; HO-1, heme oxygenase 1.