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. 2022 Feb 2;10:672391. doi: 10.3389/fcell.2022.672391

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Copyright © 2022 Sun, Wu, Yu, Zhang, Shen, Chen, Tong, Fan, Shi and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-205 overexpression inhibited cell ferroptosis and enhanced cell survival under H/R conditions by regulating ACSL4. (A) Cell proliferation was evaluated using CCK-8 assays 24 h after transfection. (B) Iron accumulation was monitored at 24 h in miR-205–overexpressing cells with or without ACSL4 overexpression followed by H/R exposure. (C) Intracellular ROS levels measured using fluorescence assays. Bar = 50 µm. Data represent the mean ± SD of three independent experiments. ^*** p < 0.001 vs. the untreated group. ^### p < 0.001 vs. the H/R + control group. ^$ p < 0.05 vs. the H/R + miR-205 mimic group.