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. 2022 Feb 2;13:773264. doi: 10.3389/fimmu.2022.773264

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Copyright © 2022 Lin, Wang, Xiong, Zhou, Yang, Chen, Xu, Zhou, Mao, Lv, Wang and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immune landscape of GBM. (A) Immune landscape of GBMs where each point represents a patient, and the immune subtypes are color-coded. The horizontal axis represents the first principal component, and the vertical axis represents the second principal component. (B) Heat map of two principal components with 28 immune cell signatures. Immune landscape of samples from (C) two extreme locations and (D) their prognostic status. (E) Immune landscape of the subsets of GBM immune subtypes. (F) Different subsets in IS3 associated with different prognoses. Immune assessment of different subsets in IS3, represented by (G) immune score, (H) stromal score, (I) estimate score and (J) tumor purity. *p < 0.05, **p < 0.01, ***p < 0.001.