Table 3:
Hazard ratios for the conventional model, conventional model + continuous PRS and conventional model + categorical PRS
| Conventional model | Conventional model + continuous PRS | Conventional model + categorical PRS | SCORE2-OP + continuous PRS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95%CI | p-value | HR | 95%CI | p-value | HR | 95%CI | p-value | HR | 95%CI | p-value | |
| Age | 1.09 | (1.06–1.12) | <0.001 | 1.09 | (1.06–1.12) | <0.001 | 1.09 | (1.06–1.12) | <0.001 | |||
| Female Sex | 0.48 | (0.34–0.67) | <0.001 | 0.46 | (0.33–0.65) | <0.001 | 0.47 | (0.34–0.66) | <0.001 | |||
| Current Smoking | 2.00 | (1.09–3.68) | 0.025 | 2.02 | (1.10–3.71) | 0.024 | 2.01 | (1.09–3.69) | 0.025 | |||
| SBP per 10 mmHg increase | 1.04 | (0.96–1.13) | 0.34 | 1.04 | (0.96–1.13) | 0.37 | 1.04 | (0.96–1.13) | 0.33 | |||
| Non-HDL-c | 1.35 | (1.17–1.56) | <0.001 | 1.35 | (1.17–1.55) | <0.001 | 1.34 | (1.17–1.55) | <0.001 | |||
| HDL-c | 0.65 | (0.44–0.95) | 0.026 | 0.65 | (0.44–0.95) | 0.027 | 0.64 | (0.44–0.94) | 0.024 | |||
| Diabetes | 0.82 | (0.49–1.38) | 0.45 | 0.81 | (0.48–1.36) | 0.42 | 0.81 | (0.48–1.36) | 0.42 | |||
| Creatinine | 1.83 | (1.03–3.26) | 0.040 | 1.81 | (1.01–3.23) | 0.045 | 1.82 | (1.02–3.24) | 0.043 | |||
| SCORE2-OP per 1% risk increase | 1.13 | (1.10; 1.16) | <0.001 | |||||||||
| PRS (continuous per SD) | 1.24 | (1.08–1.42) | 0.002 | 1.24 | (1.09; 1.42) | 0.001 | ||||||
| PRS 1st Tertile | 1.00 | (Reference) | ||||||||||
| PRS 2nd Tertile | 1.48 | (1.04–2.09) | 0.029 | |||||||||
| PRS 3rd Tertile | 1.64 | (1.16–2.33) | 0.005 | |||||||||
Abbreviations: SBP = systolic blood pressure, HDL-c = high density lipoprotein cholesterol, PRS = polygenic risk score, HR = hazard ratio, CI = confidence interval.