Table 4:

Categorical net reclassification improvement table after adding PRS to the conventional model to predict the risk of a 5-year CHD event.

		Standard Model + Polygenic Risk Score
	Standard Model	< 1.5%	1.5 to 2.49%	≥ 2.5%	Total No. (%) of participants
CHD events	< 1.5%	37	9	0	46 (22)
	1.5 to 2.49%	6	35	12	53 (25)
	≥ 2.5%	0	8	103	111 (53)
	Total No. (%) of participants	43 (20)	52 (25)	115 (55)	210 (100)
CHD non-events	< 1.5%	2248	157	2	2407 (49)
	1.5 to 2.49%	204	854	149	1207 (25)
	≥ 2.5%	1	187	1114	1302 (26)
	Total No. (%) of participants	2453 (50)	1198 (24)	1265 (26)	4916 (100)

In this table the reclassification of participants from one risk category (<1.5% risk, 1-5-2.49% risk, ≥2.5% risk) to another category is described, when adding the Polygenic risk score to the standard model. The table is further by CHD events and CHD non-events. Light gray shaded boxes indicate the correct reclassification into a different risk category, while dark gray shaded boxes indicate the incorrect reclassification into a different risk category.