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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Circ Genom Precis Med. 2021 Dec 28;15(1):e003365. doi: 10.1161/CIRCGEN.121.003365

Figure 2. Manhattan plot of IGA and MetaXcan results demonstrating tissue-specific gene expression associated with CAD genetic risk loci.

Figure 2.

Upper panel, candidate CAD causal genes identified by integrating STARNET eQTLs (9 tissue/cell types) and UKBB GWAS data.1 Y axis denotes −log10(MetaXcan P value). Only genes with a MetaXcan P value < 5x10−8 (dashed red line) are shown. The tissue where the most significant MetaXcan P value was observed is color coded. Lower panel, candidate CAD causal genes identified using the same IGA pipeline by integrating STARNET eQTLs and CARDIoGRAMplusC4D CAD GWAS.