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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Circ Genom Precis Med. 2021 Dec 28;15(1):e003365. doi: 10.1161/CIRCGEN.121.003365

Figure 6. Key GRNs and inferred regulatory interactions of candidate causal CAD genes.

Figure 6.

(A) In STARNET, GRN 154 is a cross-tissue module with 940 genes of which 61.3% are co-expressed in AOR, 31.3% in MAM, 5.6% in SKLM, and <1% each in VAF, SF, BLOOD and LIV. This IGA identified multiple candidate causal CAD genes in this GRN: PAN2, PHACTR1, SMG6, THOC5 (all in AOR), and MRAS in SKLM (Supplemental Table XII). The visualized network shows inferred gene regulatory interactions among key drivers and their related genes of GRN 154, comprising 372 inferred interactions between 281 genes (out of 940). In this GRN, the candidate causal CAD genes (yellow arrows) were found in non-key driver roles. (B) Close-up view of the second-order network neighborhood of PAN2, PHACTR1, SMG6 and MRAS in GRN 154.