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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Circ Genom Precis Med. 2021 Dec 28;15(1):e003365. doi: 10.1161/CIRCGEN.121.003365

Figure 7. Certain candidate causal CAD genes function as key drivers in GRNs.

Figure 7.

(A) STARNET GRN 39, which is exclusively in AOR and contains 182 genes. GRN 39 includes 3 candidate causal CAD genes with a key driver role: ABHD2, CAMK1D, PDGFD, which are each highlighted by a blue arrow (Table 2). In addition, in non-key driver roles GRN 39 includes CDH13 and MFGE8 (Supplemental Table XII), which are highlighted by yellow arrows. (B) STARNET GRN 171, which is exclusively in LIV and contains 200 genes. GRN 171 includes only 1 causal CAD gene with a key driver role, being TGFβ1 (blue arrow) (Table 2). There are no other candidate causal CAD genes in this GRN.