Table 1. Top 25 prioritized candidate causal genes for CAD identified using our IGA pipeline with either UKBB¹ with STARNET,¹² or, CARDIoGRAMplusC4D² with STARNET.¹².

Candidate causal genes were prioritized based on the smallest P value for the class 1 analyses (MetaXcan or SMR), however, for all of these top 25 candidate causal genes the most significant P value was obtained with MetaXcan (as opposed to SMR). Full results for all 162 candidate causal genes are in Supplemental Table VII.

Candidate casual CAD gene	Most significant P value	Tissue with most significant P value	GWAS used in IGA with most significant P value (UKBB or CaridoG)	Causal in that tissue in UKBB, CaridoG, or Both
CDKN2B	2.16x10−47	AOR	UKBB	Both
PHACTR1	3.65x10−42	MAM	CardioG	Both
TBC1D7	2.40x10−39	MAM	CardioG	Both
GFOD1	2.64x10−34	MAM	CardioG	Both
PSRC1	3.40x10−24	BLOOD	UKBB	Both
SORT1	1.18x10−23	LIV	UKBB	Both
CELSR2	5.19x10−23	LIV	UKBB	Both
MRPS6	1.96x10−22	AOR	UKBB	Both
SLC5A3	1.96x10−22	AOR	UKBB	Both
SARS	2.42x10−20	LIV	UKBB	Both
KCNE2	8.19x10−20	AOR	UKBB	CardioG
NBEAL1	4.04x10−18	AOR	UKBB	Both
ICA1L	1.08x10−17	AOR	UKBB	Both
CARF	1.79x10−17	MP	UKBB	Both
LIPA	1.58x10−15	LIV	UKBB	Both
GGCX	3.94x10−13	SF	UKBB	Both
TWIST1	3.97x10−13	AOR	UKBB	Both
VAMP5	1.11x10−12	MP	UKBB	Both
VAMP8	1.13x10−12	FC	UKBB	CardioG
FES	1.39x10−12	VAF	UKBB	Both
MIA3	2.56x10−12	FC	UKBB	Both
KIAA1462	5.86x10−12	MAM	UKBB	Both
PDGFD	6.28x10−12	MAM	UKBB	Both
FURIN	1.07x10−11	AOR	UKBB	Both
MAT2A	2.33x10−11	AOR	UKBB	Both