. Author manuscript; available in PMC: 2023 Feb 1.

Published in final edited form as: Circ Genom Precis Med. 2021 Dec 28;15(1):e003365. doi: 10.1161/CIRCGEN.121.003365

Table 2. Candidate causal CAD genes that are also key drivers of a GRN in the same tissue.

Candidate causal CAD genes in this table represent those identified in the IGA performed using STARNET and either UKBB or CARDIoGRAMplusC4D, where the tissue of causality in the IGA is the same tissue where the gene is also a key driver of a GRN. Note that STARNET does not yet have curated GRNs for MP and FC. Therefore this table only considered AOR, MAM, LIV, BLOOD, VAF, SF and SKLM. BMI, body mass index; CAD DGE, the enrichment of differential gene expression in the module between cases and controls; WHR, waist-hip ratio.

Candidate causal CAD gene	Causal gene using UKBB or CardioG	Tissue(s) of effect in IGA	Tissue in which causal gene is operative in STARNET GRN	STARNET GRN number	Number of genes in GRN	Top phenotypic associations of GRN
ABHD2	UKBB, CardioG	AOR, MAM	AOR	39	182	BMI, LDL-C, HDL-C, HBA1C
AP000350.5	UKBB	AOR, LIV, MAM, VAF	VAF	175	569	BMI, WHR, TG, Chol
ARNT	UKBB	BLOOD, SF, VAF	VAF	36	307	BMI, LDL-C, TG, HBA1C
ARNT	UKBB	BLOOD, SF, VAF	SF	137	299	BMI, LDL-C, HDH-C, WHR
ARVCF	UKBB	AOR	AOR	74	124	LDL-C, HDL-C, BMI, CRP
ATP5G1	CardioG	SKLM, VAF	VAF	75	95	WHR, TG, HBA1C, CRP
CAMK1D	UKBB	AOR	AOR	39	182	BMI, LDL-C, HDL-C, HBA1C
CNNM2	UKBB, CardioG	MAM	MAM	191	169	BMI, CRP, LDL-C, HDL-C
CTD-3253I12.1	CG	MAM	MAM	120	795	CRP, CAD DGE, WHR, BMI
DHX58	UKBB, CardioG	AOR, BLOOD, LIV, MAM, SF, SKLM, VAF	AOR	139	104	BMI, LDL-C, CRP, TG
EIF2B2	CG	FC, MAM, MP, SF	SF	198	1624	BMI, WHR, HDL-C, LDL-C
FAM192A	CG	AOR, LIV, MAM, SF, SKLM	MAM	110	283	CRP, LDL-C, BMI, WHR
FAM192A	CG	AOR, LIV, MAM, SF, SKLM	SF	118	214	CAD DGE, BMI, LDL-C, TG
FCHO1	UKBB, CardioG	BLOOD, FC, LIV, MP	BLOOD	133	57	WHR, TG, Duke, BMI
LIPA	UKBB, CardioG	AOR, BLOOD, LIV, MP, SKLM, VAF	VAF	67	98	BMI, WHR, TG, HBA1C
LIPA	UKBB, CardioG	AOR, BLOOD, LIV, MP, SKLM, VAF	AOR	150	64	LDL-C, Chol, Duke, BMI
NT5C2	UKBB, CardioG	AOR, BLOOD	AOR	177	407	BMI, LDL-C, HDL-C, Syntax
PDGFD	UKBB, CardioG	AOR, MAM	AOR	39	182	BMI, LDL-C, HDL-C, HBA1C
PLTP	CardioG	AOR, SF, VAF	AOR	122	766	LDL-C, Chol, BMI, Duke
REST	UKBB, CardioG	AOR, MAM, MP	AOR	35	223	HDL-C, LDL-C, CRP, Duke
SARS	UKBB, CardioG	LIV, VAF	LIV	92	72	BMI, WHR, TG, CRP
SCD	UKBB	SF, VAF	SF	78	1403	BMI, HBA1C, WHR, TG
STAT2	UKBB, CardioG	FC, LIV, MP, SF, VAF	SF	60	457	BMI, LDL-C, HDL-C, WHR
TGFβ1	UKBB, CardioG	LIV, SKLM	LIV	171	200	LDL-C, BMI, TG, HBA1C
THOC5	UKBB	AOR, LIV, MAM, SF, SKLM, VAF	VAF	140	89	BMI, LDL-C, WHR, TG
THOC5	UKBB	AOR, LIV, MAM, SF, SKLM, VAF	SF	60	457	BMI, LDL-C, HDL-C, WHR