KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
HIF-2-alpha Antibody	Bethyl Laboratories	Cat# 179483;
Ki67 Antibody	Cell Signaling	Cat#12202T
Actin Antibody	Protein Tech	Cat# 60008–1-Ig
Cleaved Caspase 3	Cell Signaling	Cat#9661T
Puromycin Antibody	Developmental Studies Hybridoma Bank	Cat# PMY-2A4
4-HNE Antibody	Bioss Antibodies	Cat# BS-6313R
Anti-p-histone H2A	Sigma	Cat#ZMS05636
Bacterial and Virus Strains
Wildtype L. reuteri	Robert L. Britton	N/A
Mutant L. reuteri	Robert L. Britton	N/A
Chemicals, Peptides, and Recombinant Proteins
FG-4592	Cayman Chemical	Cat#15294
N-acetyl-cysteine	Cayman Chemical	Cat#20261
Sodium Sulfide	Cayman Chemical	Cat#10122555
Cystathionine	Cayman Chemical	Cat# 16061
Olaparib	Cayman Chemical	Cat#10621
CX-5461	Cayman Chemical	Cat#18392
L-Threonine	Sigma	Cat# 72-19-5
Ammonia Chloride	Sigma	Cat#213330
5-Fluorouracil	Sigma	Cat#F6627
L-carnitine	Sigma	Cat#21489
Aspartic Acid	Sigma	Cat#1043819
L-Glutamic Acid	Sigma	Cat#G1251
L-Glutamine	Sigma	Cat#G8540
Hydrogen Peroxide	Sigma	Cat#HX0636
L-Buthionine-Sulfozimine	Cayman Chemical	Cat#14484
Glutathione Ethyl Ester	Cayman Chemnical	Cat#14953
Orotic Acid	Sigma	Cat#O2750
Ureidosuccinic Acid	Cayman Chemical	Cat#34126
Deposited Data
16S Sequencing	Yachida et. al, 2019	PMID: 31171880
16S Sequencing	Chen et. al, 2012	PMID: 22761885
16S Sequencing	Cheng Tao Pu, 2020	PMID: 31609493
16S Sequencing	GEO	GSE186880
Experimental Models: Cell Lines
NCM460	ATCC	N/A
HCT116	ATCC	N/A
MC38	ATCC	N/A
CT26	ATCC	N/A
DLD1	ATCC	N/A
SW480	ATCC	N/A
RKO	ATCC	N/A
HF27	ATCC	N/A
HF29	ATCC	N/A
MCF10A	ATCC	N/A
Vero2	ATCC	N/A
HCN2	ATCC	N/A
NCM356	ATCC	N/A
CRL1831	ATCC	N/A
CCD18Co	ATCC	N/A
Experimental Models: Organisms/Strains
Wildtype: C56Bl/6J	Jackson Labs	N/A
SingleMut: CDX2-ERT2Cre; Apcfl/fl	Jackson Labs	N/A
DoubleMut: CDX2-ERT2Cre; Apcfl/fl;Trp53fl/	Jackson Labs	N/A
TripleMut: Apcfl/fl;Trp53fl/fl; KrasLSLG12D	Jackson Labs	N/A
Oligonucleotides
List of primers	Supplemental Table 6	N/A