Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 15;12:2550. doi: 10.1038/s41598-022-06395-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Saccharin preference and burrowing performance. (a) Age-dependent differences in saccharin preference, shown as total saccharin intake, were only detected in female mice: preference for saccharin in prepubescent and pubescent mice exceeded that of the adult control group, and prepubescent mice showed a higher preference than the respective sexually mature mice (F(4,45) = 6.495, p = 0.0003). Regardless of sex, burrowing performance overnight (first test) increased significantly in mice reaching sexual maturity (b, first test; interaction p = 0.5912, age phase p < 0.0001, sex p = 0.0051) (c, second test; interaction p = 0.6044, age phase p < 0.0001, sex p < 0.0020). A difference between sexes was only detected in the second burrowing test during the light phase in young adult animals (d) (interaction p = 0.2394, age phase p = 0.0068, sex p = 0.0119). One-way ANOVA, followed by Bonferroni multiple comparison tests for (a), and two-way ANOVA, followed by Bonferroni multiple comparison tests for (b–d). *p < 0.05. Colored dots refer to the respective age groups. Error bars indicate the standard error of the mean (SEM).