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. 2022 Feb 15;13:879. doi: 10.1038/s41467-022-28531-1

Fig. 1. Disease stage-dependent alterations in the basal inflammatory status of mdx BMDM.

Fig. 1

a–c The basal mRNA transcript levels (expressed relative to the mean age-matched WT level) of prototypical M1 (iNOS, TNF, IL6, and IL12α) and M2 (TGFβ, CD206, YM1, and Arg1) marker genes during the: a prenecrotic (n = 4 for iNOS, TNF, IL12α, Arg1 genes in mdx; rest n = 5/group), b necrotic (n = 5 for WT, n = 4 for mdx), and c fibrotic phases (n = 4 for WT, n = 5 for mdx) of disease, are shown. The relative levels of phospho-STAT1, total STAT1, phospho-STAT3 and total STAT3 in cell lysates of WT and mdx BMDM from the same disease phases (d–f, respectively; all experimental replicates are shown) are also demonstrated; d (n = 5/group), e (n = 5/group), f (n = 4 for WT, n = 5 for mdx). Data represent means ± SEM of biologically independent samples from different mice. *P < 0.05 vs. WT (unpaired t-test, two-tailed). See Source Data file for the exact P-values.