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. 2022 Feb 2;13:791922. doi: 10.3389/fphar.2022.791922

TABLE 1.

The effect of cytokines on CYPs expression.

Cytokine CYPs Effects on CYPs mRNA or protein or activity Condition Studies
IL-6 CYP1A1 ↓ mRNA and protein Human HepG2 hepatoma cells Fukuda and Sassa (1994)
CYP1A2 ↓ mRNA Hepatoma cells (HepG2, HepG2f and Hep3B) Fukuda et al. (1992)
Turpentine-induced aseptic inflammation in IL-6-deficient mice Siewert et al. (2000)
Human HepaRG hepatoma cell line Rubin et al. (2015)
↓ Activity Human HepaRG hepatoma cell line Rubin et al. (2015)
↑ Activity Clinical study in patients with active rheumatoid arthritis Zhuang et al. (2015)
CYP2A5 ↓ mRNA Turpentine-induced aseptic inflammation in IL-6-deficient mice Siewert et al. (2000)
CYP2A12 ↓ Activity IL-6 knockout mice after LPS administration Warren et al. (2001)
CYP2B6 ↓ mRNA Human primary hepatocytes Aitken and Morgan (2007)
Human HepaRG hepatoma cell line Rubin et al. (2015)
↓ Activity Human HepaRG hepatoma cell line Rubin et al. (2015)
CYP2C8 ↓ mRNA Human primary hepatocytes Aitken and Morgan (2007)
CYP2C9 ↓ mRNA Human primary hepatocytes Aitken and Morgan (2007)
Activity Clinical study in patients with active rheumatoid arthritis Zhuang et al. (2015)
CYP2C19 ↓ mRNA Human primary hepatocytes Aitken and Morgan (2007)
Activity Clinical study in patients with active rheumatoid arthritis Zhuang et al. (2015)
CYP2E1 ↓ mRNA Human primary hepatocytes Abdel-Razzak et al. (1993)
CYP3 subfamily ↓ Activity Clinical study in patients with active rheumatoid arthritis Zhuang et al. (2015)
CYP3A3 ↓ mRNA Hepatoma cells (HepG2, HepG2f and Hep3B) Fukuda et al. (1992)
CYP3A4 ↓ mRNA Both HepG2 and Caco-2 cells Enokiya et al. (2021)
Human primary hepatocytes Aitken and Morgan (2007)
Activity Clinical study in patients with rheumatoid arthritis Lee et al. (2017)
Clinical study in patients with rheumatoid arthritis Schmitt et al. (2011)
Human HepaRG hepatoma cell line Rubin et al. (2015)
CYP3A5 ↓ mRNA Both HepG2 and Caco-2 cells Enokiya et al. (2021)
CYP3A11 ↓ mRNA Turpentine-induced aseptic inflammation in IL-6-deficient mice Siewert et al. (2000)
TNF-α CYP1A1 ↓ mRNA and protein Rat liver epithelial WB-F344 cells Umannová et al. (2008)
CYP1A2 ↓ mRNA Human primary hepatocytes Dallas et al. (2012)
CYP1B1 ↑ mRNA and protein Rat liver epithelial WB-F344 cells Umannová et al. (2008)
CYP2A4/5 ↑ mRNA C. rodentium mice model of infectious colitis Nyagode et al. (2014)
CYP2C8 ↓ mRNA Cynomolgus hepatocytes Uno et al. (2020)
CYP2C76 ↓ mRNA Cynomolgus hepatocytes Uno et al. (2020)
CYP2D6 ↓ mRNA Human primary hepatocytes Dallas et al. (2012)
CYP2E1 ↓ mRNA Human primary hepatocytes Abdel-Razzak et al. (1993)
CYP3A11 ↓ mRNA Mouse hepatocytes Kinloch et al. (2011)
C. rodentium mice model of infectious colitis Nyagode et al. (2014)
CYP3A25 ↓ mRNA Mouse hepatocytes Kinloch et al. (2011)
C. rodentium mice model of infectious colitis Nyagode et al. (2014)
CYP3A4 ↓ mRNA Human primary hepatocytes Dallas et al. (2012)
IL-1 CYP1A1 ↓ mRNA Isolated rat hepatocytes Barker et al. (1992)
cultured rabbit hepatocytes Calleja et al. (1997)
CYP1A2 ↓ mRNA Isolated rat hepatocytes Barker et al. (1992)
cultured rabbit hepatocytes Calleja et al. (1997)
IL-1β CYP1A1 ↓ mRNA Cynomolgus hepatocytes Uno et al. (2020)
CYP1A2 ↓ mRNA Human primary hepatocytes Abdel-Razzak et al. (1993)
CYP2B6 ↓ mRNA Human hepatocytes Assenat et al. (2004)
CYP2C8 ↓ mRNA Cynomolgus hepatocytes Uno et al. (2020)
CYP2C9 ↓ mRNA Human hepatocytes Assenat et al. (2004)
CYP2C11 ↓ mRNA IL-1β-induced fevered rat Kihara et al. (1998)
CYP2C19 ↓ mRNA Cynomolgus hepatocytes Uno et al. (2020)
CYP2C76 ↓ mRNA Cynomolgus hepatocytes Uno et al. (2020)
CYP3A4 ↓ mRNA Human hepatocytes Assenat et al. (2004)
CYP3A5 ↑ mRNA Cynomolgus hepatocytes Uno et al. (2020)
CYP3A subfamily ↓ mRNA IL-1β-induced fevered rat Kihara et al. (1998)
IFN-γ CYP1A2 ↓ Protein Human primary hepatocytes Donato et al. (1997)
CYP2B9 ↓ mRNA LPS-induced septic mice model Nyagode et al. (2010)
CYP2D9 ↓ mRNA C. rodentium-induced colitis mice model Nyagode et al. (2010)
CYP2D22 ↓ mRNA C. rodentium-induced colitis mice model; LPS-induced septic mice model Nyagode et al. (2010)
CYP2E1 ↓ mRNA LPS-induced septic mice model Nyagode et al. (2010)
CYP3A1 ↓ mRNA Rat primary hepatocytes Tapner et al. (1996)
CYP3A2 ↓ mRNA Rat primary hepatocytes Tapner et al. (1996)
CYP3A4 ↓ Protein Human primary hepatocytes Donato et al. (1997)
CYP3A11 ↓ mRNA C. rodentium-induced colitis mice model Nyagode et al. (2010)
CYP3A25 ↓ mRNA C. rodentium-induced colitis mice model Nyagode et al. (2010)
CYP4F18 ↓ mRNA C. rodentium-induced colitis mice model Nyagode et al. (2010)

Abbreviations: COVID-19, coronavirus disease 2019; CYP, cytochrome P450; IL, interleukin; TNF, tumor necrosis factor; IFN, interferon; LPS, lipopolysaccharide. ↑ (Increased), ↓ (Reduced).