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. 2022 Feb 2;9:787423. doi: 10.3389/fcvm.2022.787423

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Copyright © 2022 Neves, Koh, Souza-Silva, Passos, Silva, Velikkakam, Villani, Coelho, Brodskyn, Teixeira, Gollob, Nunes and Dutra.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cellular immune profile of cytokines and immunoregulatory receptors in T-cell subpopulations in different cardiomyopathies. Frequency of expression of cytokines and immunoregulatory receptors (A) IFN-gamma, (B) TNF, (C) IL-10 (D) IL-17 (E) IL-10R, (F) TNF-R1. The analysis was performed as described in the materials and methods for comparison between the different groups in CD4⁺, CD8⁺, gamma-delta⁺ (CCC, n = 17, IDC, n = 13) and alpha-beta⁺ DN T cells (CCC, n = 10, IDC, n = 10). (G) analysis of the ratio of TNFR1+/IL10R+ cells in CD4⁺ and CD8⁺ T cells; TNF expression in CD8⁺ T cells stimulated with PMA/Ionomycin (CCC, n = 7; IDC, n = 8). Values of p < 0.05 were considered statistically significant. Graphs are expressed as boxplots, with the minimum and maximum values indicated.