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. 2022 Feb 2;9:787423. doi: 10.3389/fcvm.2022.787423

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Copyright © 2022 Neves, Koh, Souza-Silva, Passos, Silva, Velikkakam, Villani, Coelho, Brodskyn, Teixeira, Gollob, Nunes and Dutra.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In silico analysis shows association between CD8 and CD4 mRNA with cytotoxic molecules in CCC and IDC hearts, respectively. (A) In silico comparative analysis between the expression of gene transcripts of molecules related to the function of CD4⁺ and CD8⁺ cells in cardiac tissue samples from patients with chronic Chagas cardiomyopathy (CCC, n = 10) and healthy donors (CTL, n = 7) (B) Correlation analysis between the intensity of CD8 and CD4 mRNA expression and functional molecules associated with inflammatory, regulatory, cytotoxic, and cardiotropic function in the CCC and CTL group. (C) Comparative analysis between the expression of gene transcripts of molecules related to the function of CD4⁺ and CD8⁺ cells in cardiac tissue samples from patients with idiopathic cardiomyopathy (IDC, n = 7) and Healthy donors (CTL, n = 8) (D) Correlation analysis between the intensity of CD4 and CD8 mRNA expression and functional molecules associated with inflammatory, regulatory, cytotoxic and cardiotropic function in the IDC and CTL group. Microarray data were available in Expression Omnibus databases for download [GEO- (http://www.ncbi.nlm.nih.gov/geo/)] were downloaded and subjected to statistical analysis by Graphpad Prism 8; Parametric data were analyzed by the test Student's t and non-parametric by Mann–Whitney test. Values of p < 0.05 were considered statistically significant. Pearson's test performed correlation analysis. *p < 0.05, *** and ****p < 0.0001.