Aminoglycosides or polymyxin monotherapy might be an alternative for urinary tract infections (UTIs) caused by extensively drug-resistant (XDR) P. aeruginosa.

Aminoglycosides or polymyxin monotherapy was not associated with poor outcomes compared to other antibiotic regimens.

Patients treated with antibiotic regimens other than aminoglycosides or polymyxin monotherapy were more likely to have Clostridioides difficile infection

These results may be useful for antimicrobial stewardship activities.