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. 2022 Feb 15;12:8. doi: 10.1038/s41387-022-00185-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Schematic representation of the mouse model showing the groups, pregnancies and weaning. B The network that describes the lipid traffic associated with this model, including tissues whose activity is typically associated with diet-driven diabetes. The termini represent traffic flow from synthesis (liver), for structural purposes (CNS), fatty acid oxidation (heart, vastus, liver) and storage (adipose). This metabolic relationship between tissues was used as the structure of the network for all analyses in the present study. Lean refers to mice fed exclusively a diet of normal chow ad libitum whereas Obese refers to mice fed a high fat diet drawn from mainly dairy fat sources.