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. 2022 Feb 2;9:746359. doi: 10.3389/fcell.2021.746359

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Copyright © 2022 Lai, Keller, Santos, Schaft, Dörrie and Vera.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sensitivity analysis of model parameters. (A) The heat map shows the time-dependent sensitivity indices of model parameters. The bar plots show (B) average time-dependent sensitivity indices of model parameters and (C) sensitivity indices of model parameters to the total amount of memory T cells. The main effect (blue bar) measures the direct contribution from an individual parameter to the model variable, while the total effect (red bar) measures the overall contribution including direct contribution and the amplification of the direct contribution due to interaction with all model parameters. Each graph shows the result for the most 15 sensitive parameters. The sensitivity indices of all parameters can be found in Supplementary Table S4.