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. 2022 Feb 2;9:746359. doi: 10.3389/fcell.2021.746359

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Copyright © 2022 Lai, Keller, Santos, Schaft, Dörrie and Vera.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Simulations of memory T-cell dynamics by perturbing the values of sensitive parameters. The response of memory T cells to the modulation of (A) total amount of NF-κB, (B) degradation rate of IκBα mRNA, (C) degradation rate of IKK, (D) degradation rate of IL-6 mRNA, and (E) IL-8 mRNA. The steady state of memory T cells was determined at t = 4000 h. Each parameter was perturbed within the interval (the estimated value × [0.1, 10]).