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. 2022 Feb 2;9:781436. doi: 10.3389/fcvm.2022.781436

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Copyright © 2022 Douna, de Mol, Amersfoort, Schaftenaar, Kiss, Suur, Kroner, Binder, Bot, Van Puijvelde, Kuiper and Foks.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adoptive transfer of IFNγ-B protects against atherosclerosis. ApoE^−/− mice were fed a Western type diet for 7 weeks. After 2 weeks they received a perivascular collar and were treated with PBS, freshly isolated B cells (B cells) or B cells stimulated with 20.0 ng/ml IFNγ for 24 h (IFNγ-B cells). Mice received a total of three injections and injections were spaced every two weeks. After 7 weeks, mice were sacrificed and (A) total lesion volume and (B) media size was determined in the right carotid artery with a hematoxylin and eosin staining. Lesion phenotype was determined in sections containing the largest lesions. (C) Macrophage content was analyzed using a MOMA-2 staining. (D) Collagen content was quantified with a Trichrome staining. Data are analyzed with a One-Way ANOVA and shown as mean ± SEM (*p < 0.05, **p < 0.01). n = 8–12/group.