Table 1.
Number and demographic characteristics of stroke cases identified in UK Biobank (UKB).
| Stroke definition | Number of cases | Number of controls | Mean (median) age at recruitment (years) | Mean (median) age; age range at stroke (years) | Sex (% female) |
|---|---|---|---|---|---|
| Stroke-specific code from hospital/death records | 6,887 | 401,323 | 61 (63) | 63 (64); 31 to 79 | 40 |
| Stroke-specific code from primary care | 3,976 | 404,234 | 61 (63) | 59 (61); 1 to 79 | 41 |
| Stroke-specific code from any medical setting | 8,665 | 399,545 | 61 (63) | 61 (63); 1 to 79 | 41 |
| Broad CVD code from hospital/death records | 5,725 | 402,485 | 62 (63) | 64 (65); 31 to 79 | 43 |
| Broad CVD code from primary care | 4,003 | 404,207 | 62 (63) | 62 (63); 1 to 79 | 41 |
| Broad CVD code from any medical setting | 8,085 | 400,125 | 62 (63) | 63 (64); 1 to 79 | 44 |
| Stroke-specific or broad CVD code from hospital/death records | 12,612 | 395,598 | 61 (63) | 63 (64); 31 to 79 | 41 |
| Stroke-specific or broad CVD code from primary care | 7,979 | 400,231 | 62 (63) | 60 (62); 1 to 79 | 41 |
| Stroke-specific or broad CVD code from any medical setting | 16,750 | 391,460 | 62 (63) | 62 (63); 1 to 79 | 42 |
| Specific self-reported stroke event | 5,915 | 402,295 | 61 (62) | 53 (55); 0 to 70 | 41 |
| Specific or non-specific self-reported stroke event | 7,536 | 400,674 | 61 (63) | 53 (55); 0 to 70 | 42 |
| Any code or self-reported event | 19,449 | 388,761 | 61 (63) | 60 (61); 0 to 79 | 43 |
| Across all UKB participants | 408,210 | 57 (58) | Not applicable | 54 | |
We considered code and self-reported event age missing if it predated the date of birth, contained a negative value, or was recorded by UKB as unreliable or missing–this affected 0.3% to 2.1% cases depending on the stroke definition. CVD, cerebrovascular disease. Bold represents combined groups, e.g. broad CVD code from hospital/death + broad CVD from primary care = broad CVD code from any medical setting.