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. 2022 Feb 2;13:770948. doi: 10.3389/fnagi.2021.770948

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Copyright © 2022 Li, Li, Dai, Yang, Liang, Wang, Liu, Chen and Tao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Electro-acupuncture (EA) treatment activates the MS/VDB-DG cholinergic neural circuit improving the pattern separation impairment in 5 × FAD mice. Exploration of mice during novel location recognition (NLR) pre-treatment (A) and post-treatment (B). Each circle represents a mouse, and n = 10/group. Results of the location discrimination (LD) task are expressed as trails of MIT (C), the accuracy of PIT (D), and trails of LDR (E) (n = 8/group). Data are represented as mean ± SD (*p < 0.05 and ^**p < 0.01 vs WT group; ▲▲p < 0.01 vs 5 × FAD group; ^##p < 0.01 vs 5 × FAD + EA group; ^&p < 0.05 vs 5 × FAD + EA + hM4Di group). NLR, novel location recognition; MTT, must touch training; PIT, punish incorrect training; LDR, location discrimination reversal.