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. 2022 Feb 2;13:770948. doi: 10.3389/fnagi.2021.770948

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Copyright © 2022 Li, Li, Dai, Yang, Liang, Wang, Liu, Chen and Tao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EA treatment activates the MS/VDB-DG cholinergic neural circuit promoting hippocampus neurogenesis in 5 × FAD mice. Representative images of doublecortin (DCX) (A) and Neuro-D1 (B) in the DG. Groups were subjected to immunofluorescence labeling with Dapi (Blue), DCX or Neuro-D1 (red) staining. Scale bar = 100 μm. Quantified DCX positive cells (C) and Neuro-D1 positive cells (D). Data are represented as mean ± SD, n = 4/group (^**p < 0.01 vs WT group; ▲p < 0.05 and ▲▲p < 0.01 vs 5 × FAD group; ^#p < 0.05 and ^##p < 0.01 vs 5 × FAD + EA group; ^&p < 0.05 and ^&&p < 0.01 vs 5 × FAD + EA + hM4Di group). DCX, doublecortin; Neuro-D1, neurogenic differentiation factor 1.