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. 2022 Feb 2;13:770948. doi: 10.3389/fnagi.2021.770948

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Copyright © 2022 Li, Li, Dai, Yang, Liang, Wang, Liu, Chen and Tao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary drawing of the experimental findings. The present study included two parts: Baihui (DU20) and Shenting (DU24) acupoints with EA stimulation in 3-month-old 5 × FAD mice (upper), and the pattern separation ability was improved after EA treatment (middle). It was found that the alteration of the cholinergic system in MS/VDB and DG (left, bottom), the increased of the M1 muscarinic receptors and hippocampal neurogenesis in the DG via activating of the MS/VDB-DG cholinergic neural circuit (right, bottom). EA treatment normalized the pattern separation performance in FAD mice, which was related to activating the MS/VDB-DG neural circuit, regulating the M1 muscarinic receptors and promoting hippocampal neurogenesis in DG.