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. 2022 Feb 11;221(4):e202009037. doi: 10.1083/jcb.202009037

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© 2022 Cho et al.

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Figure 9. — Proposed model of tTJ formation mediated by tricellulin–α-catenin interaction. In WT epithelial cells, an actin meshwork forms around tricellular junctions concurrent with the maturation of bicellular adhesions. The tricellular actin meshwork is anchored to the central sealing elements by the tricellulin–α-catenin–vinculin complex. Myosin-driven contractility brings the converging central sealing elements in close contact and closes the central tube. Because the anchorage between the central sealing elements and the actin filaments is lost in Tric KO cells, myosin cannot act at tTJs, which results in the formation of gaps at tricellular junctions.