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. 2022 Jan 22;24:321–331. doi: 10.1016/j.omtm.2022.01.012

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Hematopoietic differentiation and HIV resistance of macrophages from CRISPR-Cas9-CCR5 modified HSPCs

(A) Morphology of macrophages generated from parental and CRISPR-modified HSPCs in unsorted cells. RFP indicated cells transduced with the CCR5-CRISPR vectors in differentiated macrophages. (B) Flow cytometric analysis of macrophage-specific markers in macrophages generated from CRISPR-modified HSPCs after enrichment of TagRFP⁺ cells by FACS. (C) Resistance of macrophage from CCR5-CRISPR-modified HSPCs to HIV-1 infection compared with unmodified cells. The assay was performed in triplicate, and error bars represent standard deviation.