Table 2.
Genotyping results and inheritance models calculations
|
rs41423247 NR3C1:c.1184+646C>G |
rs6265 BDNF:c.442G>A |
||||
|
Genotype |
MDD (%, n) |
Control (%, n) |
Genotype |
MDD (%, n) |
Control (%, n) |
|
CC |
46.34%, n=38 |
49.30%, n=141 |
GG |
63.41%, n=52 |
60.69%, n=173 |
|
CG |
40.24%, n=33 |
43.01%, n=123 |
GA |
34.15%, n=28 |
34.42%, n=99 |
|
GG |
13.41%, n=11 |
7.69%, n=22 |
AA |
2.44%, n=2 |
4.90%, n=14 |
|
|
HWE, p=0.38 |
HWE, p=0.50 |
|
HWE, p=0.43 |
HWE, p=0.97 |
|
Dominant model OR=1.13, 95%CI: (0.69, 1.84); χ2=0.12, p=0.72 |
Dominant model OR=0.88, 95%CI: (0.53, 1.47); χ2=0.12, p=0.73 |
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|
Recessive model OR=1.86, 95%CI: (0.86, 4.01); χ2=1.90, p=0.16 |
Recessive model OR=0.49, 95%CI: (0.11, 2.18); χ2=0.43, p=0.51 |
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|
Allelic model OR=1.22, 95%CI: (0.84, 1.77); χ2=0.94, p=0.33 |
Allelic model OR=0.85, 95%CI: (0.55, 1.31); χ2=0.40, p=0.53 |
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BDNF: Brain-derived neurotrophic factor; CI: Confidence interval; HWE: Hardy–Weinberg equilibrium; MDD: Major depressive disorder; n: No. of cases; NR3C1: Nuclear receptor subfamily 3 group C member 1; OR: Odds ratio