Table 3.
Prognostic factors associated with HCC recurrence.
| Variable | Comparison | Univariate | Multivariate | ||
|---|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | ||
| Age (years) | Per 1-year increase | 1.013 (1.004-1.023) | 0.004 | ||
| Sex | Male vs Female | 1.140 (0.848-1.532) | 0.387 | ||
| Diabetes mellitus | Yes vs No | 1.467 (1.182-1.819) | <0.001 | 1.426 (1.133-1.795) | 0.003 |
| Hypertension | Yes vs No | 1.173 (0.950-1.447) | 0.138 | ||
| Alcohol drinking | Current vs Never/Past | 1.018 (0.811-1.278) | 0.877 | ||
| Smoking | Current vs Never/Past | 1.125 (0.907-1.396) | 0.283 | ||
| HCC family history | Yes vs No | 1.263 (0.966-1.652) | 0.088 | ||
| Platelet (109/L) | <150 vs ≧150 | 1.467 (1.185-1.815) | <0.001 | ||
| AFP (ng/mL) | >10 vs ≦10 | 1.205 (0.977-1.486) | 0.082 | ||
| Child-Pugh class | B vs A | 0.897 (0.335-2.406) | 0.830 | ||
| ALBI grade | II/III vs I | 1.095 (0.850-1.409) | 0.483 | ||
| Liver cirrhosis | Yes vs No | 1.983 (1.607-2.448) | <0.001 | 1.965 (1.571-2.458) | <0.001 |
| BCLC stage | A vs 0 | 1.382 (1.066-1.791) | 0.015 | ||
| Tumor no. | Multiple vs Single | 1.291 (0.966-1.724) | 0.084 | 1.350 (1.007-1.809) | 0.045 |
| Tumor size (cm) | Per 1 increase | 1.075 (1.011-1.143) | 0.020 | 1.108 (1.035-1.187) | 0.003 |
| Histology stages | Poor/Moderate vs Well | 1.241 (0.944-1.632) | 0.122 | ||
| Microvascular invasion | Yes vs No | 1.303 (1.041-1.629) | 0.021 | ||
| Capsule invasion | Yes vs No | 1.130 (0.880-1.452) | 0.338 | ||
| Satellite nodules | Yes vs No | 2.314 (1.421-3.768) | 0.001 | 1.910 (1.094-3.333) | 0.023 |
| MAFLD | Yes vs No | 0.923 (0.750-1.135) | 0.445 | ||
| Etiology of HCC | CHB vs NBNC | 1.250 (0.963-1.624) | 0.094 | 1.339 (1.010-1.775) | 0.043 |
HR, hazard ratio; CI, confidence interval; AFP, alpha fetoprotein; ALBI, albumin-bilirubin; HCC, hepatocellular carcinoma; MAFLD, metabolic associated fatty liver disease.