FIGURE 4.

Mitochondrial redistribution and function in wound healing. The schematic represents an overview of mitochondrial contribution in the series of events during the wound healing process. Upon injury, cells in the damaged tissue lose contact with each other forming a lesion in the tissue (A). In response to the wounding, cytoplasmic calcium (purple) and ROS (pink) levels increase locally at the wound site ROS (pink) is also released extracellularly at the wound site (B) (Wright et al., 2008; Guo et al., 2017; Guo et al., 2020). Small, fragmented mitochondria (green) in cells adjacent to the wound site redistribute towards the wound site. Inflammatory cells and immune cells (beige) migrate towards the wound site in response to ROS. Mitochondria (green) are localized at the uropods of these cells (C) (Campello et al., 2006; Morlino et al., 2014). This is followed by tissue morphogenesis and closure aided by increased actomyosin (blue–Actin, yellow–Myosin) based constriction and loss of E-cadherin (magenta) (C,D) (Fu et al., 2020; Ponte et al., 2020). Only a few of the references that have led to the figure compilation have been cited here.