FIGURE 5.

Mitochondrial morphology function in cellularization in Drosophila embryogenesis. Small round mitochondria migrate apically during cellularization in Drosophila embryos. Schematic represents the terminal timepoints of cellularization in control, Drp1 mutant and SOD mutant embryos. Light to dark pink shades represent increasing levels of ROS in these cells. Control embryos have apically migrated small mitochondria (green). Myosin II (yellow) is localized at basal contractile rings. Clustered mitochondria (green) in Drp1 mutant embryos accumulate basally and fail to migrate apically. Lowered ROS levels (light pink), lead to decreased Myosin II (yellow) and contractility at the contractile rings. These cells are shorter than controls with large contractile rings. SOD mutant embryos have high ROS levels (dark pink) and small mitochondria (green) are present apically. These cells show increased Myosin II (yellow) levels with increased contractility and smaller rings. They are taller compared to controls (Chowdhary et al., 2020).