Table 1.
Peptides that target tumor vasculature and lymphatics.
| Peptide Ligand | Cellular Target | Refs. |
|---|---|---|
| Targeting Tumor Vasculature | ||
| CDCRGDCFC (RGD-4C) | αv β3, αv β5 | [87, 88] |
| ACDCRGDCFCG | αv β3, αv β5 | [89] |
| CNGRCVSGCAGRC | Aminopeptidase N | [90] |
| TAASGVRSMH, LTLRWVGLMS | NG2 proteoglycan | [91] |
| CGSLVRC, CGLSDSC | Vasculature of various tumors | [28] |
| NRSLKRISNKRIRRK, LRIKRKRRKRKKTRK, NRSTHI | IC-12 rat tracheal tumor | [92] |
| SMSIARL, VSFLEYR | Mice prostate | [93] |
| CPGPEGAGC | Aminopeptidase P | [94] |
| ATWLPPR | VEGF | [95] |
| RRKRRR | VEGF | [96] |
| ASSSYPLIHWRPWAR | VEGF | [97] |
| CTTHWGFTLC | Gelatinase | [98] |
| Ciso DGRCG | αv β3, αv β5 | [99] |
| cyclo[(3R,6S)DKP-isoDGR], cyclo[(3S,6R)DKP-isoDGR] | αv β3, αv β5 | [100] |
| CTPSPFSHC | Unknown | [101] |
| CSRPRRSEC, CGKRK, CDTRL | Unknown | [102] |
| CKAAKNK, CKGAKAR, CRGRRST |
First two unknown Last one PDGF-β |
[103, 104] |
| CRGDK/RGPD/EC (iRGD) | αvβ3, αvβ5, neuropilin-1 | [79, 80] |
| CPRECESIC | Aminopeptidase A | [105] |
| CGNSNPKSC | Unknown | [106] |
| SVSVGMKPSPRP | Unknown | [107] |
| IFLLWQR | Annexin 1 | [108] |
| Targeting Tumor Lymphatics | ||
| CGNKRTRGC (LyP-1) | p32/gC1qR | [72, 109, 110] |
| CNRRTKAGC, CLSDGKRKC, CREAGRKAC, CAGRRSAYC | [110, 111] | |