Table 2.
Peptides that target specific cancer types.
| Cancer Type | Peptide Ligand | Cellular Target | Refs. |
|---|---|---|---|
| Human lymphoma | KNGPWYAYTGRO, NWAVWXKR, YXXEDLRRR XXPVDHGL |
Surface idiotype of SUP-88 human B-cell lympoma | [104, 154] |
| LVRSTGQFV, LVSPSGSWT ALRPSGEWL, AIMASGQWL QILASGRWL, RRPSHAMAR DNNRPANSM, LQDRLRFAT PLSGDKSST |
Surface idiotype of human chronic lymphocytic leukaemia (CLL) | [155] | |
| IELLQAR | HL 60 human lymphoma & B-16 mouse melanoma | [156] | |
| SAKTAVSQRVWLPSHRGGEP, KSREHVNNSACPSKRITAAL, WLSEAGPVVTVRALRGTGSW |
A20 | [157] | |
| CAYHRLRRC | Molt-4 | [158] | |
| Myeloma | FDDARL, FSDARL, FSDMRL FVDVRL, FTDIRL, FNDYRL FSDTRL, PIHYIF, YIHYIF, RIHYIF |
Human multiple myeloma M-protein | [159] |
| Prostate cancer | CVFXXXYXXC CXFXXXYXYLMC CVXYCXXXXCYVC CVXYCXXXXCWXC |
Prostate-specific antigen (PSA) | [160] |
| DPRATPGS | LNCaP | [161] | |
| SHGFSRHSMTLI | Capan-2 (irradiated) | [162] | |
| FRPNRAQDYNTN | DU-145 | [163] | |
| IAGLATPGWSHWLAL | PC-3 | [164] | |
| CREAGRKAC (REA) | Prostate Tumors from TRAMP mice | [111] | |
| Breast cancer | VPWMEPAYQRFL | MDA-MB435 breast cancer | [165] |
| YQATPARFYTNT, CGWMGLELC | MDA-MB-231 | [166] | |
| LTVSPWY WNLPWYYSVSPT | SKBR3 | [138] | |
| CNGRCVSGCAGRC (NGR), CDCRGDCFC (RGD-4C) | MDA-MB-435, Amino-peptidase N & αvβ3, α5β1 | [28] | |
| Neuroblastoma | HLQIQPWYPQIS VPWMEPAYQRFL | WAC-2 human neuroblastoma | [165] |
| Head and neck cancer | TSPLNIHNGQKL | MDA Tu167 head and neck cancer lines | [167] |
| Laryngeal carcinoma | RLTGGKGVG | HEp-2 human laryngeal carcinoma | [168] |
| RLLDTNRPLLPY | NPC-TW 04 | [169] | |
| EDIKPKTSLAFR | Nasopharyngeal carcinoma (CNE-1) | [170] | |
| Hepatocarcinoma | TACHQHVRMVRP | BEL-7402 | [171] |
| KSLSRHDHIHHH | SMMC-7721 | [172] | |
| SFSIIHTPILPL | Mahlavu | [173] | |
| Melanoma | CTVALPGGYVRVC | GRP78 | [174] |
| TRTKLPRLHLQS | B16-F10 | [175] | |
| CLSDGKRKC (LSD) | C8161 Melanoma | [111] | |
| Gastric | GRRTRSRRLRRS | XGC9811-L4 | [176] |
| SMSIASPYIALE | GC9811-P | [177] | |
| SWKLPPS | AZ-P7a, α3β1 | [178] | |
| CGNSNPKSC | Human gastric adenocarcinoma, α3β1 | [179] | |
| Colon | CPIEDRPMC, | HT29 | [180] |
| HEWSYLAPYPWF, QIDRWFDAVQWL | WiDr | [166] | |
| VRPMPLQ | Human Colonic adenomas | [181] | |
| SPTKSNS | Resected human colon tumors | [182] | |
| VHLGYAT | SW480 | [183] | |
| VGLPEHTQ, ELRGDSLP, | |||
| Glioma | DSTKSGNM, DYDMTKNT, DLTKSTAP, ESRGDSYA, |
RG2 | [184] |
| MCPKHPLGC | U87-MG | [185] | |
| Cervical | CRLTGGKGVGC, CADPNSVRAMC, CAAHYRVGPWC | SiHa | [186] |
| Medullary Thyroid |
CHTFEPVGC | TT | [187] |
| SRESPHP | Medullary thyroid carcinoma (RET-C634R transgenic mice) |
[188] | |
| Rhabdomyosarcoma | CQQSNRGDRKRC, CMGNKRSAKRPC | αvβ3 | [138] |
| Leukemia | CPLDIDFYC | Kasumi-1 α4β1 | [189] |
| KDEPQRRSARLSAKPAPPKPEPK-PKKAPAKK | Human myeloid leukemia (HL-60) | [190] | |
| Lung cancer | VSQTMRQTAVPLLWFWTGSL, YAAWPASGAWTGTAPCSAGT, EHMALTYPFRPP |
H1299 (large cell) | [191–193] |
| RGDLATLRQLAQEDGVGVR | H2009 αvβ6 | [191] | |
| MTVCNASQRQAHAQATAVSL | A549 | [191] | |
| TDSILRSYDWTY | CL1-5 | [194] | |
| HVGGSSV | Lewis lung carcinoma (irradiated/SU11248) | [195] | |
| SVSVGMKPSPRP | Lung (CL1-5) | [107] | |
| Bladder | CSNRDARRC | HT-1376 | [196] |
| Pancreatic | KTLLPTP | Pancreatic ductal carcinomas arising from Kras/p52L/L mice, Plectin-1 |
[197] |
| CRGRRST, CRSRKG, CKAAKNK, CKGAKAR, FRVGVADV |
RIP1-Tag2 mice Pancreatic islets PDGFRβ | [103] | |
| Oral | SVSVGMKPSPRP, SNPFSKPYGLTV, WDSNTYTPRPLM |
Oral (SAS) | [107, 198] |
| Squamous carcinoma | CGKRK, CDTRL | K14-HPV16 mice basal cell | [102] |