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. Author manuscript; available in PMC: 2022 Feb 16.
Published in final edited form as: Bioorg Med Chem Lett. 2020 Mar 30;30(11):127162. doi: 10.1016/j.bmcl.2020.127162

Table 1.

Antiviral Activity and Cytotoxicity of Compounds 16–24a

graphic file with name nihms-1581701-t0006.jpg
Compd R1 EC50 (μM)
 CC50(μM)
D-1 D-2 D-3 D-4
1 graphic file with name nihms-1581701-t0007.jpg 2.4 0.11 0.006 >10 >10
16 graphic file with name nihms-1581701-t0008.jpg NT 4.2 NT NT NT
17 graphic file with name nihms-1581701-t0009.jpg NT >5 NT NT NT
18 graphic file with name nihms-1581701-t0010.jpg NT >5 NT NT NT
19 graphic file with name nihms-1581701-t0011.jpg NT >5 NT NT NT
20 graphic file with name nihms-1581701-t0012.jpg NT >5 NT NT NT
21 graphic file with name nihms-1581701-t0013.jpg 1.8 0.062 >5 >5 >10
22 graphic file with name nihms-1581701-t0014.jpg 1.8 0.050 0.019 >5 >10
23 graphic file with name nihms-1581701-t0015.jpg 2.3 0.14 0.39 >5 >10
24 graphic file with name nihms-1581701-t0016.jpg 1.6 0.038 0.017 >5 >10
a

EC50 values were determined on Huh7 cells stably expressing DENV-1 to -4 replicon; CC50 values were measured using Huh7 cells stably expressing DENV-2 replicon; D-1: DENV-1; D-2: DENV-2; D-3: DENV-3; D-4: DENV-4; NT: not tested.