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. Author manuscript; available in PMC: 2022 Feb 16.
Published in final edited form as: Bioorg Med Chem Lett. 2020 Mar 30;30(11):127162. doi: 10.1016/j.bmcl.2020.127162

Table 2.

Antiviral Activity and Cytotoxicity of Compounds 25–32a

graphic file with name nihms-1581701-t0017.jpg
Compd R2 R3 EC50 (μM)
 CC50(μM)
D-1 D-2 D-3 D-4
25 NT 4.4 NT NT >10
26 NT 1.1 NT NT >10
27 CH3 H 2.5 1.8 0.025 >5 >10
28 graphic file with name nihms-1581701-t0018.jpg H NT 1.9 NT NT >10
29 NT >5 NT NT NT
30 H graphic file with name nihms-1581701-t0019.jpg NT >10 NT NT >20
31 H CN NT 8.6 NT NT 50
32 H graphic file with name nihms-1581701-t0020.jpg NT 3.2 NT NT 50
a

EC50 values were determined on Huh7 cells stably expressing DENV-1 to -4 replicon; CC50 values were measured using Huh7 cells stably expressing DENV-2 replicon; D-1: DENV-1; D-2: DENV-2; D-3: DENV-3; D-4: DENV-4; NT: not tested.