Table 2:
Hub phenotypes in the UKBB DDN
| Phenotype | PheCode | Disease category |
|---|---|---|
| Skin cancer | 172 | Neoplasm |
| Diabetes mellitus | 250 | Endocrine/metabolic |
| Hypothyroidism | 244 | Endocrine/metabolic |
| Hypothyroidism NOS | 244.4 | Endocrine/metabolic |
| Type 1 diabetes | 250.1 | Endocrine/metabolic |
| Type 2 diabetes | 250.2 | Endocrine/metabolic |
| Disorders of lipoid metabolism | 272 | Endocrine/metabolic |
| Hyperlipidemia | 272.1 | Endocrine/metabolic |
| Other retinal disorders | 362 | Sense organs |
| Hypertension | 401 | Circulatory system |
| Essential hypertension | 401.1 | Circulatory system |
| Coronary atherosclerosis | 411.4 | Circulatory system |
| Non-celiac intestinal malabsorption | 557 | Digestive |
| Celiac disease | 557.1 | Digestive |
| Psoriasis | 696 | Dermatologic |
| Psoriasis NOS | 696.4 | Dermatologic |
| Other inflammatory polyarthropathies | 714 | Musculoskeletal |
| Rheumatoid arthritis | 714.1 | Musculoskeletal |
| Disorders of muscle, ligament, and fascia | 728 | Musculoskeletal |
| Fasciitis | 728.7 | Musculoskeletal |
Centrality measures used to identify these phenotypes included degree, weighted degree, closeness centrality, betweenness centrality, and eigenvector centrality. Diseases marked in boldface appear multiple times as the most central nodes based upon our different network measures. Supplementary Table S1 provides the exact centrality measures that identified each phenotype to be a hub. NOS: not otherwise specified.