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. 2022 Jan;10(2):90. doi: 10.21037/atm-21-6868

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2022 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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The anti-apoptotic and proliferation promoting effect of OE-FNDC5 on BMSCs subjected to H/SD injury. (A) EdU staining analysis demonstrated that OE-FNDC5 promoted the proliferation of BMSCs subjected to H/SD for 24 h. Proliferation rate = (EdU-positive nuclei/DAPI-positive nuclei) × 100%. (B) Representative flow cytometric images indicated that OE-FNDC5 decreased the apoptosis rate of BMSCs caused by hypoxia. (C) Western blot results of apoptosis proteins, Bax and Bcl2, in BMSCs with or without OE-FNDC5. *, P<0.05; **, P<0.01. Scale bar =100 µm. H/SD, hypoxia/serum deprivation; OE-FNDC5, FNDC5-overexpression; EdU, 5-ethynyl-2'-deoxyuridine.