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. 2022 Jan;10(2):83. doi: 10.21037/atm-21-6857

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2022 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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YTHDF3 enhances ZEB1 mRNA stability in an m⁶A-dependent manner. (A) RNA-binding protein immunoprecipitation (RIP) assay confirmed that YTHDF3 can bind to ZEB1 mRNA in MDA-MB-231 and BT-549 cells. (B) RIP assay validated that ZEB1 mRNA was modified with m⁶A modification in MDA-MB-231 and BT-549 cells. (C,D) The mRNA stability analysis verified that ZEB1 mRNA was drastically decreased after YTHDF3 knockdown in MDA-MB-231 and BT-549 cells. *, P<0.05; **, P<0.01; ***, P<0.001. YTHDF3, the YTH domain family 3; ZEB1, zinc finger E-box-binding homeobox 1; m⁶A, N6-methyladenosine.