Table 2. Univariate and multivariate cox proportional hazard model for DFS and OS in TNBC patients.
| Variables | Univariate analysis | Multivariate analysis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DFS | OS | DFS | OS | ||||||||||
| HR (95% CI) | Pa | HR (95% CI) | Pa | HR (95% CI) | Pa | HR (95% CI) | Pa | ||||||
| Age (years) | |||||||||||||
| ≤50 | Reference | Reference | Reference | ||||||||||
| >50 | 0.56 (0.34–0.95) | 0.031 | 0.81 (0.43–1.55) | 0.526 | 0.76 (0.44–1.30) | 0.308 | |||||||
| Tumor size | |||||||||||||
| ≤2 cm | Reference | Reference | Reference | Reference | |||||||||
| >2 cm | 1.97 (1.12–3.46) | 0.019 | 2.09 (1.01–4.32) | 0.046 | 2.08 (1.17–3.71) | 0.013 | 2.07 (1.01–4.27) | 0.049 | |||||
| Lymph nodes metastasis | |||||||||||||
| No | Reference | Reference | Reference | Reference | |||||||||
| Yes | 2.25 (1.34–3.79) | 0.002 | 2.46 (1.27–4.78) | 0.008 | 1.85 (1.08–3.17) | 0.026 | 2.24 (1.15–4.36) | 0.018 | |||||
| Grade | |||||||||||||
| I + II | Reference | Reference | Reference | ||||||||||
| III | 1.94 (1.08–3.49) | 0.026 | 1.99 (0.94–4.22) | 0.072 | 1.83 (1.01–3.31) | 0.047 | |||||||
| Lymphovascular invasion | |||||||||||||
| No | Reference | Reference | Reference | ||||||||||
| Yes | 1.73(1.04–2.88) | 0.036 | 1.76 (0.92–3.36) | 0.086 | 1.59 (0.94–2.70) | 0.084 | |||||||
| YTHDF3 expression | |||||||||||||
| Low | Reference | Reference | Reference | Reference | |||||||||
| High | 2.22 (1.31–3.74) | 0.003 | 2.21 (1.14–4.30) | 0.019 | 1.93 (1.14–3.28) | 0.015 | 1.99 (1.02–3.86) | 0.044 | |||||
a, the P value was adjusted by the univariate Cox proportional hazard regression model. DFS, disease free survival; OS, overall survival; TNBC, triple-negative breast cancer; HR, hazard ratio; CI, confidence interval; YTHDF3, the YTH domain family 3.